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Oral administration has the benefit of high patient compliance and has demonstrated the potential to target brain iron pathology, especially with BBB-permeant agents like DFP

PSC mainly affects the large bile ducts with a characteristic pattern of multifocal strictures and dilations, while PBC targets small intrahepatic bile ducts

Notably, while classical organoid systems have long been established exclusively from crypt-resident stem cells 27,28 , our findings challenge this longstanding paradigm by demonstrating that mutation-free villus-derived cells can indeed establish organoids via fetal reversion, revealing remarkable regenerative flexibility of the adult intestinal epithelium