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(2) Excessive inflammatory mediators trigger the infiltration of inflammatory cells, which then release a multitude of cytokines, such as transforming growth factors and fibroblast growth factors

7E) [142]

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The ERK is a key signalling pathway downstream of BDNF, and alteration of the phosphorylation pattern of both CREB and ERK has been proposed as a mechanism contributing to neurodegenerative diseases (Gourley et al