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1a), the active Mn III center responsible for superoxide anion (O 2 ) dismutation is coordinated with a solvent molecule (OH ) and a histidine (His 27) in trans-axial positions, as well as two histidines (His 75 and His 164) and one aspartate (Asp 160) in the equatorial plane, forming a distorted pentacoordinated trigonal bipyramidal geometry 1

8 A survey reported that with the development of the economy and increased life pressure, MDD has begun to emerge at a younger age, and the incidence of MDD in women is approximately twice that in men

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