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This requires overcoming challenges related to inter-individual variability, methodological standardization, establishing causality, and ensuring the stability and generalizability of biomarkers across diverse populations, as emphasized in studies focusing on decoding the complex microbiota metabolome (164)

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doi: 10.1016/j.bcp.2024.116604 90 WangWHuKXueJChenJDuXZhaoTet al

Other animal models of FM include the chronic constriction injury model, which involves the compression of a nerve to induce neuropathic pain 37 , and the ovariectomy model, which involves the removal of the ovaries to induce hormonal changes that may be associated with FM 37