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The Compound Classes Most Studied in Tendon Research Tendon healing is limited by three biological constraints: low resident cell density (tenocytes proliferate slowly), poor vascularization (tendons have limited baseline blood supply), and structured extracellular matrix requirements (collagen must reorganize into the correct fibril architecture for functional recovery)

Cartilage inflammation is harder to detect because cartilage does not swell or show clear immune cell movement

Increasing GSH and/or GSH-dependent antioxidant enzymes directly Many studies have concentrated on the direct effects of synthetic drugs on GSH and GSH-dependent antioxidant enzymes in damaged myocardium without further mechanistic investigations

These diagnostic criteria and classification were largely endorsed by an international group of experts in 2012 and have slightly evolved since then with the addition of two other MCAS categories: combined or mixed (patients meeting criteria for primary and secondary MCAS) and hereditary alpha-tryptasemia(HT)-associated MCAS (patients with either primary, secondary or idiopathic MCAS and HT) [3]