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In another study, PCA administration significantly prevented colitis symptoms, reduced pro-inflammatory cytokines and liver toxicity markers, and protected against oxidative damage in both the colon and liver, highlighting its chemoprotective role [360]

18 , 19 , 20 Furthermore, a high expression of STAT3 alters the cell cycle 21 , 22 and inhibits the apoptosis by upregulating anti-apoptotic signaling 23 , 24 in inflammation-associated CRC and other human cancers

In summary, this study demonstrates that calcium overload plays a critical role in the cytotoxicity associated with a-synucleinopathy, leading to mitochondrial damage, lysosomal dysfunction, and cell death

Although approved multi-agent chemotherapy regimens offer an incremental advance over single-agent treatments, the best available treatment cocktails are only marginally effective, and virtually all PDAC eventually becomes resistant to these treatments ( 1, 2 )