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This binding activates antioxidant signaling pathways, including GPX4 and FSP1

Critical role of oxidative stress and sustained JNK activation in aloe-emodin-mediated apoptotic cell death in human hepatoma cells

Retinol-binding protein (RBP) is a plasma protein, and transports vitamin A to peripheral tissues after synthesis in liver cells and fat cells (118)

Phenols 6-gingerol is a monophenolic compound derived from rhizome of Zingiber officinale Roscoe [222], which can promote ferroptosis of lung cancer in vitro and in vivo by inhibiting the expression of autophagy-related protein ubiquitin-specific peptidase 14 (USP14) and regulating the downstream of autophagy-dependent ferroptosis [223]