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These changes create self-reinforcing pathological cycles that worsen tissue function and promote systemic insulin resistance ( AT comprises distinct depots (white, brown, beige, and pink) with unique physiological functions and metabolic characteristics ( At the molecular level, adipose dysfunction involves cellular stress responses, aberrant inflammatory signaling, and dysregulated microRNA networks

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Several drugs have been studied, but none have demonstrated significant benefits, indicating a need for larger, well-designed, controlled trials

NETosis is a type of programmed cell death distinct from apoptosis and necrosis