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Deficiency of GPx results in direct tissue damage and activation of age-related NF-B inflammatory pathways [57]

These factors determine the brain's capacity for learning and memory at the most fundamental level

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While nutritional VC intake demonstrates chemopreventive effects by scavenging carcinogen-induced reactive oxygen species (ROS) and maintaining genomic stability, high-dose intravenous VC acts as a prooxidant to selectively kill tumor cells via ROS-mediated deoxyribonucleic acid (DNA) damage, adenosine triphosphate (ATP) depletion, and HIF-1 degradation