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Federico A, Dallio M, Gravina AG, et al

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BCRF-supported research covers a range of topics regarding this subtype: Developing ways to better predict prognosis and improve outcomes for patients with HER2-positive breast cancer Refining current biomarkers used to define HER2-positive breast cancer and assessing how they vary between patients, during tumor progression and metastasis within a single tumor, and throughout therapy Developing a more precise test to measure HER2-low levels so that more patients can benefit from HER2-targeted therapies Improving HER2-targeted therapies with a particular focus on how immune cells in the HER2-positive breast tumor microenvironment influence a tumors response to treatment Testing the clinical and immunologic activity of a novel anti-HER2 antibody therapy in early-stage, HER2-positive breast cancer Understanding what drives treatment response and resistance in patients with HER2-positive breast cancer BCRF researchers are also seeking to gain a better understanding of the metastatic process, including in HER2-positive breast cancer