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doi: 10.1152/ajpgi.00044.2006 135 AngelopoulouRLavranosGManolakouP

Significant improvement in anti-inflammatory response, improvement in sleep levels, reduction in blood pressure, improvement in short term memory, improvement in reported feelings of vitality and consistency in reporting across the study suggest that further research with a larger sample size be done and confirm the previously reported anecdotal responses in the testing of earlier subjects

The discovery of COX isozymes led to the development of selective COX-2 inhibitors, the first one being celecoxib