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Excessive and chronic alcohol use can alter brain chemistry, resulting in alcohol cravings, dependency, and ultimately, addiction to alcohol

However, administration of BSO could rescue the decreased mEPSC frequency brought by MeAIB (Fig

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For grade 2 toxicities, we may consider holding treatment, and then resuming when symptoms or lab values improve to normal or to grade 1, or we may consider low-dose steroids like 0.5 to 1 mg/kg per day of prednisone for grade 2. For grade 1, asymptomatic or minimally symptomatic irAEs, or where findings are confined to a radiographic or laboratory change, supportive care and/or localized therapy on an outpatient basis, continuation of the ICI at full dose, and increased frequency of monitoring are recommended