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DNA damage results in activation of ATM and ATR, which results in stabilization of the TP53 protein causing increased levels of cell cycle inhibitors, including CDKN1A/p21 Cip , CDKN1B/p27 Kip1 , and CDKN1C/p57 Kip2 [33]

On the other hand, testosterone may increase male vulnerability to an adverse illness course compared to estrogen 56 , attributed to its narrower and sometimes unfavorable neuroprotection and neurotransmitter modulation profile 57

For the determination of arteriovenous difference, we measure the partial pressure of oxygen in the samples of the flowing in and out solution of the heart using a gas analyzer BMS3Mk2 (Denmark)

The involvement of abnormal cholesterol metabolism is also important in cancer development