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In contrast, UC is primarily influenced by cytokines like IL-4, IL-5, IL-10, and IL-13 produced by Th2-type T cells

Carroll RC, Beattie EC, von Zastrow M, Malenka RC (2001)

doi: 10.1016/j.phymed.2025.156873 134 Del CuoreAPipitoneRMCasuccioAMazzolaMMPuleoMGPacinellaGet al

Agmatine was able to attenuate the increased glutamate levels due to chronic opioid administration.[ref] Agmatine also helps with neuropathic pain by blocking NMDA glutamate receptors.[ref] Riboflavin (vitamin B2): Riboflavin can reduce the release of glutamate from nerve terminals.[ref] This may be why riboflavin is effective in preventing migraines in some people.[ref] Saffron: A review of animal studies found that saffron appears to be able to regulate glutamate levels, reduce oxidative stress, and modulate A and tau protein aggregation.[ref] N-acetylcysteine (NAC): NAC has been shown to reduce neuronal glutamate release