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No changes to blood pressure were noted ( Meanwhile, other studies have found pine bark extract to be less effective at reducing heart disease risk ( Recent meta-analysis studies have determined that theres not enough evidence to support a link between Pycnogenol and blood pressure ( So, although pine bark extract appears to support the mechanisms of heart health, its still unclear how safe and effective it is as a treatment for specific conditions

Iranian Journal of Psychiatry and Clinical Psychology

Indeed, Microbial production of PPs using GM bacterial strains have also resulted in significant over-production of these health promising metabolites (360, 380) which can be used to expand clinical and experimental studies on PPs