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Substituting these amino acids influenced both the catabolism [49, 52] and neonatal transcytosis [52] of mouse IgG1 fragments in wild-type (WT) mice in a manner that correlated with the binding affinity of the mutated Fc fragments towards mouse FcRn at pH 6.0 [51]

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The commenters expressed concern that the measure's focus on time thresholds could put undue pressure on ED staff to rush, and that emphasizing speed over quality could compromise patient care to avoid financial penalties

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