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There are a couple of readily apparent advantages of SUMO compared to other solubility tags, such as GST and MBP: Figure 5

Clinical improvement was also noted in patients with neuropsychiatric lupus who were treated with RTX

doi: 10.1126/science.114.2952.93

Furthermore, in mild-to-moderate asthmatics with airflow limitation, low plasma selenium concentrations were also associated with greater lipid peroxidation byproducts, increased concentrations of high-sensitivity C-reactive protein, and an increased ratio of CD4+/CD8+ lymphocytes, suggesting a shift in Th2 polarization (124)