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Science 348 , 453457 (2015)

The study enrolled 617 patients, average age 62, who had never been vaccinated against shingles and were taking a TNF inhibitor for rheumatoid arthritis, psoriatic arthritis, or another condition

I have heard people saying that the B12 injections caused them to have painful muscle spasms and this was seen as being an unwanted side effect of the injection