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We focus on documented outcomes in hypermobile and classical EDS (which feature pronounced joint laxity), and discuss one example in the vascular subtype

COS-7 cells were maintained at a logarithmic growth phase in DMEM (Sigma) supplemented with 10% heat-inactivated FCS, 50 units/ml penicillin, and 50 g/ml streptomycin (complete DMEM) in 145 mm tissue culture plates (CellStar, Greiner, Germany)

Ferroptosis and the bidirectional regulatory factor p53

While gastrointestinal adverse events were more common in the semaglutide group than in the placebo group overall, these were mostly mild to moderate and occurred predominantly in the early titration phase rather than persisting throughout the two-year treatment period