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In addition to policies finalized in this final rule, we also refer readers to our discussion in section III.G.4.b(2)(a) of this final rule of previously finalized policies that support ACOs during the transition to digital quality measurement

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First, the molecular trigger specificity of oxalate-induced ferroptosis in renal tubular cells is undefinedhow oxalate precisely initiates the synergistic dysregulation of iron uptake (TFR1), lipid metabolism (ACSL4), and antioxidant defense (GPX4/SLC7A11) remains elusive, with no clarity on upstream signaling molecules or post-translational modifications that link oxalate exposure to ferroptosis machinery