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Upregulation in phenylalanine (increased PAL), tyrosine (increased TYR, HPPD), arginine/proline (increased ARG, P5CR), and glycine/serine/threonine (increased AMT, TA) metabolism serves multiple protective functions: (1) Antioxidant Production: PAL activation promotes phenolic antioxidant synthesis

The lack of Np63 expression in p53 wt breast cancer cells confirmed earlier reports and might be expected in p53 dom/neg MDD2 cells, as p53 regulated the level of Np63 through the Np63 promoter and transcriptional activation of AIP5 in cancer cells

10.1016/j.phymed.2020.153451 183 SilvaG

Foresti D, Kroll KT, Amissah R, et al