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When NNMT activity is reduced, less nicotinamide is methylated and wasted, allowing NAD pools to remain higher

ASCT, autologous stem cell transplant

The changes in the incidence of these very different diseases at exactly the time acetaminophen use dropped for a significant period of time is remarkable and may indicate the same factor as causing the two diseases

In summary, from a clinical point of view, additional mechanistic investigations of the novel natural modulators on melanogenesis are urgently required