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Under hypoxic conditions, high expression of HIF-1 and HIF-2 can induce chondrocytes to secrete MMPs and a disintegrin and metalloproteinase with thrombospondin motifs-4, promote chondrocyte apoptosis, inhibit chondrocyte autophagy, and aggravate articular cartilage destruction ( in vitro by upregulating the MAPK and JAK/STAT pathway under hypoxic conditions in the RA joint cavity ( Figure 6 )

To enhance specificity and bioavailability, folate-modified exosomal nanoplatforms (erastin@FA-exo) have been developed to deliver the system x c inhibitor erastin directly to tumor cells, selectively depleting GSH while minimizing systemic toxicity [288]

Liver fibrosis is a key determinant of disease progression, and higher fibrosis stages are associated with an increased risk of liver related complications, including cirrhosis, HCC, and liver failure [45]