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3458-A METABOLIC BIOMARKER CONSTELLATIONS ALLOW SIMULTANEOUS AND INTEGRATED LIVER AND KIDNEY FUNCTION MONITORING IN CHRONIC LIVER DISEASE Frank Stmmler 1 , Laurence Derain-Dubourg 2 , Sandrine Lemoine 2 , Jeffrey Meeusen 3 , Surendra Dasari 3 , John Lieske 3 , Andrew Robertson 1 and Eric Schiffer 1 , (1)Numares AG, (2)Hospices Civils De Lyon, (3)Mayo Clinic Background: Renal impairment often occurs in liver disease

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Protective effect of melatonin on alleviating early oxidative stress induced by DOX in mice spermatogenesis and sperm quality maintaining