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10.3389/fphar.2020.00907 Front

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Enzymology of mammalian NAD metabolism in health and disease

91 TGF- promotes EndMT in PH Canonical pathway In MCT-PAH rats, upregulation of TGF- and increased phosphorylation of Smad2 leads to elevated expression of Gal-3 and -SMA, facilitating EndMT