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Importantly, two research groups demonstrated that Set7/9-mediated methylation of Hif1a under hypoxic conditions increased the proteasomal degradation of Hif1a and hence prevented transactivation of Hif1 target genes [105, 106] (Figure 2B)

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However, calculated plasma vitamin C concentrations were approximately 70 to 80 M in both the control and treatment groups, despite supplementation in the treatment group (Padayatty & Levine, 2006)