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In addition to causing a persistent chronic inflammatory state by excessive ROS formation due to a high-fat, high-carbohydrate diet and inhibited antioxidant system, obesity can also produce systemic OS through NOX activation (43)

Some evidence suggests combining the two approaches may be superior to either alone

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Peimine inhibits the production of Proinflammatory cytokines through regulation of the phosphorylation of NF-B and MAPKs in HMC-1 cells