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Pharmacol Res 113:257264

doi: 10.1016/j.lungcan.2004.05.016 114 OrlandoLRenneGRoccaACuriglianoGColleoniMSeveriGet al

Success requires matching peptide mechanisms to disease pathology, using adequate doses achieving receptor engagement, maintaining treatment long enough for effects manifesting, combining complementary mechanisms for complex diseases, and monitoring mechanism-relevant outcomes documenting engagement