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These often-overlooked members are now recognized as integral to intestinal ecology, able to reshape microbial balance and modulate host immunity through distinct metabolic and immunological pathways 2,6

These are hard deposits made of minerals and salts that build up

182,183,184,185 For example, mutations in the TET2 gene are associated with a poor prognosis for AML, and low expression or inactivation of TET2 is common in a variety of tumors, while activation of TET2 can suppress tumor development