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From the size and sequence diversity within the GST superfamily in Arabidopsis , it is clear that there is scope for considerable functional diversification

Monocle2 pseudotime analysis further confirmed that, relative to natural aging, the additional effect of HHcy caused endothelial cells to diverge in different directions and accelerated their transition from pre-aging to senescence, as evidenced by the bifurcation at Branch Point 1 (Figure 2K)

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Altogether, by enabling the TCA cycle, Fe-S clusters take part in the controlled combustion of nutrients and supply metabolic precursors for nucleotide, lipid, and protein biogenesis