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98,100,103 Compared with those of CD8 + T cells, the diversity and output of CD4 + T cells are more stable, although some studies have indicated the accumulation of CD4 + T cells expressing PD-1 and Tregs (CD4 + CD25 + Foxp3 + ) during aging

In addition, SAMe production is reduced and methylation reactions are impaired, which are subsequently associated with a reduced methylation capacity [25]