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Normally, very large amounts of quercetin are nutritionally required to achieve some its health benefits because it's not very "bioavailable" or easy for the body to take up and use, since it's not water-soluble

2024;25(2):1294.[DOI] 194

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By attenuating oxidative damage and modulating inflammatory factors and fibrotic cytokines (eg, I/III Collagen type 1, intercellular adhesive molecule-1, fibronectin, inducible nitric oxide synthase, and arginase type 1) during disease progression, Sal B-DPI significantly alleviated bleomycin-induced pulmonary fibrosis as evidenced by the reduction of alveolar wall congestion, inflammatory cell infiltration, emphysema extent, and lung ventilatory function