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Furthermore, methotrexate (MTX), the immunosuppressant commonly used for the treatment of RA, has been demonstrated that could reduce inflammation and subsequent tissue damage by inhibiting MAA-adducts formation and scavenging superoxide in RA [108]

[193] Gundacker C, Komarnicki G, Zdl B, Forster C, Schuster E, Wittmann K

Aged T cells resist ferroptosis by limiting labile iron pool via downregulation of IRP2 One mechanism by which cells resist ferroptosis is by restriction of labile iron pool 21