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German/Austrian Aplastic Anemia Working Group

Understanding what is happening with your heart rate over time, not just in the acute moment when you notice palpitations, gives you and your provider much better information to work with

10.1016/j.ijcard.2011.06.112 85

Immune cells-particularly CD8+ T cells-are highly dependent on mitochondrial ATP supply, and this bioenergetic failure limits their proliferation, cytokine production, and cytotoxic activity, contributing to T cell exhaustion ( As noted earlier, damaged or released mtDNA activates innate immune pathways such as cGAS-STING and NLRP3, sustaining chronic inflammation and inflammaging (99)