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There was a report that Se uptake (as selenite) to the brain increased in lipopolysaccharide treated female mice, whereas in males, no increased BBB permeability for selenite was observed under such conditions (Minami et al., 2002)

Ueda, Y

Yes, while generally well-tolerated, some individuals may experience side effects such as gastrointestinal discomfort, including diarrhea, especially at higher doses