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As clinical signs of cobalamin deficiency include chronic wasting or failure to thrive, malaise, and gastrointestinal signs such as diarrhea, serum cobalamin concentration should be measured in any dog with poor response to enzyme replacement therapy for EPI

By elucidating the critical roles of ROS homeostasis in cellular physiology and disease treatment, this review aims to advance the discovery of potential biomarkers as well as the development of novel therapeutic approaches based on ROS homeostasis