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The samples of blood/liquor were collected in rated intervals (see experimental design) from the jugular vein or cisterna magna respectively, via the polyethylene tubing (BTPE10, Instech, USA) applied before the glutamate application

Biochem Pharmacol, 34(12): 2151-2156

Nevertheless, a subset of patients continues to face therapeutic challenges associated with primary/secondary treatment failure, adverse reactions, and disease heterogeneity, which has driven the development of emerging therapies based on pathological mechanisms