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However, GDNFs pleiotropic effects also present a double-edged sword, as its overexpression can promote the growth and therapy resistance of high-grade gliomas, underscoring the need for precise, targeted therapeutic strategies (Revishchin et al., 2022)

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Reported side effects are generally mild in supervised use, such as injection site reactions, but the real risks come from unregulated products, incorrect self dosing, and skipping medical evaluation