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The sensory pathway that involves Luschkas nerve explains how lower LDH may cause referred pain at the level of groin sensory nerve root, resulting in DGP

Tatewaki M, Harris M, Uemura K

This causes your weight to fluctuate, which can eventually damage your metabolism

Based on basic MichaelisMenten enzyme kinetics, by supplying the extra substrate and cofactor (i.e., folate and riboflavin) the reduced affinity can be overcome and the consequences of having the variant can be alleviated, e.g., reduction in elevated homocysteine, reduction in blood pressure, etc. This is the very definition of personalized nutrition, in this case an increased requirement of two essential nutrients based on a common genetic difference