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I.GielbertJ.GaskellS

Biologic therapies have revolutionized the management of moderate-to-severe psoriasis, particularly for individuals who do not respond to conventional systemic treatments

doi: 10.1007/s13671-018-0234-9

When the iron load increases (such as high iron reserve level, high serum iron) 25 or in cases of infection and chronic inflammation, 26 elevated hepcidin directly binds to membrane FPN, promoting its internalization as well as degradation in epithelial cells of intestinal, thereby inhibiting iron absorption into the blood