melanotic macules treatment of labial on the lip. These are benign spots that appear on the lips for no apparent reason. The causes are mostly genetic, but similar spots can appear in smokers, after A flat and oval-shaped melanotic

The results of the study, despite being conducted on only four patients, suggest that this integrative therapy should be considered, given its lack of toxicity and its ability to prolong the life of a patient considered terminal

The combination of these three factors leads to increased DNA damage, weakened cohesion, dysfunction of the spindle assembly checkpoint, and meiotic recombination errors, forming a vicious cycle that leads to the generation of chromosomal aneuploidies and, ultimately, to an age-related decline in oocyte function

Shi, M., Luo, J., Ding, L

Available from: [DOI] [PMC free article] [PubMed] [Google Scholar] 253.Kontoghiorghes G, Kontoghiorghe C