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Tanshinol A (TSA) stimulates the phosphorylation of mixed lineage kinase domain-like protein (MLKL), a necroptosis marker, leading to its translocation to the cell membrane and an increase in cytosolic calcium levels, eventually causing necroptosis in lung cancer cells [121]

How PlexusDx Supports a More Personalized Approach PlexusDx's Precision Peptide Genetic Test may help provide context for your detoxification capacity by revealing genetic predispositions in metabolic and detoxification pathwaysvariants that influence how efficiently your body produces and recycles glutathione, processes amino acids, and supports Phase II liver clearance

Access this chapter Similar content being viewed by others References Adams ML, Pierce RH, Vail ME, White CC, Tonge RP, Kavanagh TJ, Fausto N, Nelson SD, Bruschi SA (2001) Enhanced acetaminophen hepatotoxicity in transgenic mice overexpressing BCL-2

[3] Hoang AT, Nieti S, Cheng CK, et al