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According to Krithika Srikanthan et al., activation of the Na/K-ATPase signal cascade exacerbates obesity, diabetes, dyslipidemia, and atherosclerosis, and these conditions are all related to the imbalance of OS ( The nuclear factor erythroid 2-related factor 2 (NRF2) pathway is closely related to antioxidant effects and is activated at the onset of OS ( Relationship Between Increased ROS Caused by Hyperglycemia and Cardiovascular Dysfunction Hyperglycemia (high levels of blood glucose) leads to increased production of ROS, which ultimately leads to vascular dysfunction ( Another question that needs resolution is how does high blood sugar level trigger OS and lead to cardiovascular dysfunction