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The important caveats on the topical data Honesty requires naming the limitations even of the route that does have human data

For this study, cells were divided into two experimental settings: the high glucose (HG) setting, mimicking diabetes in vitro, and the standard glucose (SG) setting [23]

p53 is nicknamed the guardian of the genome because it is a tumor supressor when it detects mutation in the cells DNA (which can turn the cell into cancer), it causes apoptosis (in fact, lots of cancers are associated with genetic mutations that switch off p53, meaning that p53 stops working and cant kill the cell before it forms a tumor and possibly becomes cancerous)