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The FDA approved generic versions of Vyvanse from 11 drugmakers, including U.S.-based drugmakers Mallinckrodt and Viatris, UK-based Hikma Pharmaceuticals, and Indian drugmaker Sun Pharmaceutical Industries, last year after Takeda lost exclusivity over the drug

Initially, studying desensitization was made possible by using experimental models endogenously expressing OR such as brain membranes, rabbit cerebellum or cell lines (NG 108-15, SH-SY5Y, SK-N-SH, SK-N-BE)