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Complementary mechanisms GSH and TXN systems constitute the two thiol-based antioxidant networks that cooperate to restrain ferroptosis 115

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5.5 Lactate accumulation: acidification and inhibition of antitumor immunity In the complex, dynamic tumor microenvironment of colorectal cancer, metabolic reprogramming of cancer cellsparticularly the enhanced Warburg effectserves not only as a core strategy to meet bioenergetic and biosynthetic demands but also as a key driver of immunosuppression