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Herein, we describe a long-term high-throughput microfluidic liver chip for studying chronic liver diseases compatible with standard laboratory automation technologies

10.1111/bph.15834 112 HuM.HuangJ.ChenL.SunX

Activation of mitochondrial voltage-dependent anion channels and mitogen-activated protein kinases, upregulation of endoplasmic reticulum stress, and inhibition of cystine/glutamate antiporter is involved in the induction of ferroptosis

Four of the identified compounds have mutagenic potential (AMES negative) namely compounds 1 (Methyl methanethiolsulfonate), 13 (S-Methyl methanethiosulphonate), 26 (2-Methoxy-4-vinylphenol), and 29 (2-(hydroxymethyl)-2-nitro-1,3-)