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Furthermore, it has been found in humans and animals that nicotine enhances the learning ability (Poorthuis et al., 2009), improves neuronal plasticity in the hippocampus (Motaghinejad et al., 2016), and can treat excitotoxicity at low concentrations (Sieber, 2012)

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Supplementation is a gradual process

Over time, the circuit reasserts itself, hunger signals return at lower body weights than they would have appeared at without medication, and the patient finds that maintaining the deficit takes more deliberate effort than it did in months one through six