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Experimental Section Plasma Stability of 7-HMG The plasma stability of 7-HMG (synthesized in-house from mitragynine) was performed using heparinized pooled non-Swiss albino mouse (Innovative Research, Novi, MI), SpragueDawley rat (GeneTex, Irvine, CA), beagle dog (BioIVT, Hicksville, NY), cynomolgus monkey (BioIVT, Hicksville, NY), and human plasma (with sodium citrate as an anticoagulant