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Notably, no studies to date have specifically tested this hypothesis in patients with Hashimotos thyroiditis, limiting the generalisability of existing evidence to this particular population

Up to now AIIRA have not been extensively used in children with diabetes, but more evidence of the efficiency and safety must be available before AIIRAs can become an obvious choice for the treatment of diabetic nephropathy and hypertension in children and adolescents in the near future

References Borne, R

Interestingly, treatment withdrawal did not completely restore the mRNA transcripts, and a similar effect was observed for vitamin D metabolism genes and genes associated with NAFLD which was persistently higher, suggesting the epigenetic association between GSH deficiency and vitamin D metabolism genes